Genome-wide mutation/SNP analysis, biological characteristics, and Pan-India prevalence of SARS-CoV-2 Variants of Concern

corona virus genetics mapping in India


  • Nimita Kant University of Delhi
  • Shamashree Samanta University of Delhi
  • Ishika Panchal University of Delhi
  • Abhishek Pandey University of Delhi
  • Lagna Ghatak University of Delhi
  • Adyasha Rout University of Delhi
  • Jitendra Kumar Chaudhary University of Delhi


Covid-19, Corona virus, mutations, vaccine, therapy, genomics


The origin of COVID-19 pandemic, caused by SARS-CoV-2, was traced to Wuhan, China. Thereafter, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved into various variants owing to genome-wide mutations, causing emergence of multiple variants, including Variant of Interest and Variant of Concern. Here, we discuss genomic architecture of SARS-CoV-2, as well as its multiple variants- alpha, beta, gamma, and delta, along with their biological properties, such as transmissibility, reduction in antibody-mediated neutralization, virulence, disease severity, vaccine effectiveness, and the prevalence across the India vis-à-vis world. Our data on VOC, pooled from the Global Initiative on Sharing All Influenza Data up to 31 October 2021, shows around 89% prevalence of delta VOC across various Indian States. Whereas alpha, beta, and gamma variants show 10.44%, 0.57%, and 0.11% prevalence, respectively. Compared with global scale, the reported Indian prevalence of alpha, beta, gamma, and delta are 0.40%, 0.63%, 0.04%, and 1.7%, respectively. Furthermore, prevalent vaccines of various natures show significantly reduced effectiveness against these VOCs, necessitating urgent need for development of effective prophylactic vaccines and potential therapy to contain the pandemic.


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Author Biographies

  • Nimita Kant, University of Delhi

    Department of Zoology, Shivaji College

  • Jitendra Kumar Chaudhary, University of Delhi

    Department of Zoology, Shivaji College






How to Cite

Kant, N.; Samanta, S. .; Panchal, I.; Pandey, A.; Ghatak, L.; Rout, A.; Chaudhary, J. K. Genome-Wide Mutation SNP Analysis, Biological Characteristics, and Pan-India Prevalence of SARS-CoV-2 Variants of Concern. Chem Biol Lett 2022, 9 (2), 331.

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