Genome-wide mutation/SNP analysis, biological characteristics, and Pan-India prevalence of SARS-CoV-2 Variants of Concern

corona virus genetics mapping in India

Authors

  • Nimita Kant University of Delhi
  • Shamashree Samanta University of Delhi
  • Ishika Panchal University of Delhi
  • Abhishek Pandey University of Delhi
  • Lagna Ghatak University of Delhi
  • Adyasha Rout University of Delhi
  • Jitendra Kumar Chaudhary University of Delhi

Keywords:

Covid-19, Corona virus, mutations, vaccine, therapy, genomics

Abstract

The origin of COVID-19 pandemic, caused by SARS-CoV-2, was traced to Wuhan, China. Thereafter, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved into various variants owing to genome-wide mutations, causing emergence of multiple variants, including Variant of Interest and Variant of Concern. Here, we discuss genomic architecture of SARS-CoV-2, as well as its multiple variants- alpha, beta, gamma, and delta, along with their biological properties, such as transmissibility, reduction in antibody-mediated neutralization, virulence, disease severity, vaccine effectiveness, and the prevalence across the India vis-à-vis world. Our data on VOC, pooled from the Global Initiative on Sharing All Influenza Data up to 31 October 2021, shows around 89% prevalence of delta VOC across various Indian States. Whereas alpha, beta, and gamma variants show 10.44%, 0.57%, and 0.11% prevalence, respectively. Compared with global scale, the reported Indian prevalence of alpha, beta, gamma, and delta are 0.40%, 0.63%, 0.04%, and 1.7%, respectively. Furthermore, prevalent vaccines of various natures show significantly reduced effectiveness against these VOCs, necessitating urgent need for development of effective prophylactic vaccines and potential therapy to contain the pandemic.

Author Biographies

Nimita Kant, University of Delhi

Department of Zoology, Shivaji College

Jitendra Kumar Chaudhary, University of Delhi

Department of Zoology, Shivaji College

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Published

2022-02-16

How to Cite

Kant, N., Samanta, S. ., Panchal, I., Pandey, A., Ghatak, L., Rout, A., & Chaudhary, J. K. (2022). Genome-wide mutation/SNP analysis, biological characteristics, and Pan-India prevalence of SARS-CoV-2 Variants of Concern. Chemical Biology Letters, 9(2), 331. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/331

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