Genome-wide mutation/SNP analysis, biological characteristics, and Pan-India prevalence of SARS-CoV-2 Variants of Concern

Authors

  • Nimita Kant University of Delhi
  • Shamashree Samanta University of Delhi
  • Ishika Panchal University of Delhi
  • Abhishek Pandey University of Delhi
  • Lagna Ghatak University of Delhi
  • Adyasha Rout University of Delhi
  • Jitendra Kumar Chaudhary University of Delhi

Keywords:

Covid-19, Corona virus, mutations, vaccine, therapy, genomics

Abstract

The origin of COVID-19 pandemic, caused by SARS-CoV-2, was traced to Wuhan, China. Thereafter, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved into various variants owing to genome-wide mutations, causing emergence of multiple variants, including Variant of Interest and Variant of Concern. Here, we discuss genomic architecture of SARS-CoV-2, as well as its multiple variants- alpha, beta, gamma, and delta, along with their biological properties, such as transmissibility, reduction in antibody-mediated neutralization, virulence, disease severity, vaccine effectiveness, and the prevalence across the India vis-à-vis world. Our data on VOC, pooled from the Global Initiative on Sharing All Influenza Data up to 31 October 2021, shows around 89% prevalence of delta VOC across various Indian States. Whereas alpha, beta, and gamma variants show 10.44%, 0.57%, and 0.11% prevalence, respectively. Compared with global scale, the reported Indian prevalence of alpha, beta, gamma, and delta are 0.40%, 0.63%, 0.04%, and 1.7%, respectively. Furthermore, prevalent vaccines of various natures show significantly reduced effectiveness against these VOCs, necessitating urgent need for development of effective prophylactic vaccines and potential therapy to contain the pandemic.

Author Biographies

  • Nimita Kant, University of Delhi

    Department of Zoology, Shivaji College

  • Jitendra Kumar Chaudhary, University of Delhi

    Department of Zoology, Shivaji College

corona virus genetics mapping in India

Published

2022-02-16

Issue

Section

Articles

How to Cite

Genome-wide mutation/SNP analysis, biological characteristics, and Pan-India prevalence of SARS-CoV-2 Variants of Concern. (2022). Chemical Biology Letters, 9(2), 331. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/331

Similar Articles

1-10 of 27

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)