Synthetic strategies and medicinal applications of Quinoline-Pyrimidine hybrids

Abstract

The growing need to overcome the drug-resistance to bio-active molecules and the need for enhancement of properties in functional materials prompted the demand for new derivatives of existing moieties and development of more active new molecules. This effort culminated in the synthesis of a variety of molecules which often combined two active moieties into one single molecule such as the quinoline-pyrimidine hybrids. Quinoline-pyrimidine hybrids, though, include a wide class of molecules which vary based on the type of linkage combining the two moieties- quinoline and pyrimidine. This review focuses on these different classes of molecules, various developments in the synthesis of these hybrids and the biomedical applications of the synthesized molecules. Recently, greener methods like one-pot reactions and microwave assisted reactions have been utilized to synthesize some of the quinoline-pyrimidine hybrids and quite a few of the synthesized molecules have shown better or at par activity as the existing reference molecules.

URN:NBN:sciencein.cbl.2022.v9.318