Correlation of cardiac markers with thyroid stimulating hormone in subclinical hypothyroid elderly

Abstract

Cardiac markers ( CPK-MB and TroponinT (TnT)) are often used to differentiate between cardiac and non cardiac chest pain. Subclinical hypothyroidism (SCH) has increased incidence of cardiovascular risk factors and disease. Elderly have an increased incidence of SCH. However, no study have specifically examined the association between cardiac markers and SCH in elderly population. Aims and Objectives : To determine the association of cardiac markers with thyroid stimulating hormone (TSH) in elderly patients with subclinical hypothyroids and euthyroid. Method: The present study was designed as a retrospective cross sectional study conducted in Biochemistry department of Adesh institute of medical sciences and research (AIMSR) Bathinda from a period of May 2023 to April 2024.The data was obtained from the lab computers and the subjects were divided into four groups. Group 1 included patients who had MI and SCH. Group 2 consisted of patients who had MI and were euthyroid. Group 3 were those who presented with chest pain only ( no MI) and SCH. Group 4 were those who had acute chest pain ( no MI)  and were found to be euthyroid. Results: Group 1 and 3 showed a highly significant association between the the cardiac markers and TSH. Group 2 and 4 showed a significant correlation. Conclusion: Elevations of TSH levels may cause a significant rise in the cardiac markers in SCH as compared to euthyroid.