Formulation and evaluation of Momordica charantia fruit extract based transdermal drug delivery against diabetes

transdermal patch

Authors

Keywords:

Transdermal Drug Delivery system, Eudragit, Momordica charantia , polymer patch, Drug delivery

Abstract

Conventional medicine occupies majority of healthcare sector. But slow release and low concentration of these medicines able to reach target site.  Transdermal drug delivery system is efficient, easy to use and cost effective way to deliver medicines to target site. Therefore, present study focuses on developing matrix-type transdermal patches containing Momordica charantia fruit extract combined with various polymers. These patches are intended for transdermal drug delivery. Different combinations of polymers, plasticizers, and permeability enhancers were prepared and assessed for various physico-chemical parameters. The release of the drug in rabbit serum was evaluated using High-Performance Liquid Chromatography (HPLC). Additionally, Fourier Transform Infrared (FTIR) analysis was conducted to examine the interaction between the drug and polymers. Scanning Electron Microscopy (SEM) was employed to observe the surface topology of the patches both before and after drug permeation. The formulated patches exhibited favorable physico-chemical properties. FTIR analysis demonstrated compatibility between the drug and polymers. SEM analysis revealed uniform distribution of the drug within the matrix patch, with the presence of permeation holes indicating drug release. Formulation with polymer HPMC (A6) and with a combination of HPMC & Eudragit (A10) displayed enhanced drug release efficiency. In-vitro permeation followed first-order kinetics in ethylcellulose (A1) and HPMC & Eudragit (A10) formulations. Skin tests did not show any signs of erythema. The study's findings suggest that the developed transdermal patches, particularly those containing HPMC and HPMC & Eudragit as polymers, could be a promising option for managing diabetes through systemic drug circulation.

URN:NBN:sciencein.btl.2024.v11.905

Author Biographies

  • Utkarsh Kaushik, Poddar International College, Jaipur, India

    Department of Zoology

  • Suresh Chandra Joshi, University of Rajasthan, Jaipur

    Department of Zoology

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Published

2024-05-16

Issue

Section

Pharmaceuticals Sciences

URN

How to Cite

(1)
Kaushik, U.; Joshi, S. C. . Formulation and Evaluation of Momordica Charantia Fruit Extract Based Transdermal Drug Delivery Against Diabetes. Biomed Ther Lett 2024, 11 (1), 905.

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