Category: Readings
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In vitro anticancer and antitubercular activities of cellulose-magnetite nanocomposite synthesized using deep eutectic solvent as a dispersant
In the current scenario, Deep Eutectic Solvents (DESs) are persuasive greener solvents for the successful synthesis of different nanostructures due to their tunable properties with enhanced applications. We report here the successful formation of a nanocomposite based on cellulose and magnetite nanoparticles. The method of isolating cellulose from fruit shells of Limonia acidissima (L.) as…
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Novel 5-Nitro Isatin derivatives as DNA Gyrase inhibitors: synthesis, anti-microbial evaluation, molecular docking, ADMET predictions and QSAR studies
Novel series of 5-nitroindoline-2-ones was synthesized starting from 5-nitroindoline-2,3-dione 2 and 2-(5-nitro-2-oxoindolin-3-ylidene)hydrazine-1 carbothioamide 3. Compounds were evaluated for their antimicrobial activities. The data showed that compounds 2 and 6b have excellent antimicrobial activities against the two tested strains of G+ve bacteria Staphylococcus aureus and Streptococcus and E. coli when compared with the standards. Furthermore, in-vitro…
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Phytochemical screening, GC-MS analysis and In-vitro Antioxidant potential of Parthenium hysterophorus Stem sequentially extracted fractions
Oxidative stress (OS) is involved in pathophysiological events of different diseases. Antioxidants mitigate and suppress the adverse effect of OS in the body. Due to lesser side effects and cost effectiveness natural antioxidant is a choice of people nowadays. The present study was designed to characterize/analyze phytochemicals and antioxidant potential in Parthenium hysterophorus (Asteraceae) stem…
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Green synthesized Allium cepa nanoparticles with enhanced antiprotozoal activities for E. gingivalis
Allium cepa has phytochemical characteristics well known to be used in our gastronomy. Due to its particle size, low systemic bioavailability is the major disadvantage associated that pose major hurdle for its use for medicinal purpose. These limitations can be overcome by converting the bulk size particles to nanosized particles. The present study was to…
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Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?
Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating…
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1,3,4 Oxadiazole: An emerging scaffold to target different growth factors and kinases
Five member heterocyclic 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. The important mechanism behind tumor suppression by 1,3,4-Oxadiazole is related with the inhibition of different growth factors, enzymes and kinases etc. The 1,3,4-Oxadiazole scaffold is a five member heterocyclic…
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Medicinal applications of Saffron plant in Neurological disorders
Saffron (Crocus sativus L.) has been widely used in traditional or phytomedicine as a treatment of neurological disorders. The saffron is showing great potential to treat various neurological diseases without any apparent side effects. As there are very limited drugs available for the treatment of neurological diseases, saffron provides hope to treat the brain disorders…
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Design, synthesis, ADME prediction and anti-hyperglycemic evaluation of new alkoxyimino-substituted phenyl carboxylic acids as potent alpha-glucosidase inhibitors
In an attempt to further explore the role of substituted carboxylic acid derivatives as antidiabetic agent, a series of alkoxyimino-substituted carboxylic acid derivatives (101-206) were designed, synthesized and evaluated for their inhibitory potential against a-amylase and a-glucosidase enzyme. Among all the tested compounds, 102 & 105 has displayed the most potent activity against a-glucosidase with…
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