Acid labile linkers have been used widely for various biomedical applications with preferential applications in drug delivery. In this report, we have synthesized, glycerol based b-thiopropionate esters having an acid-labile β-thiopropionate linker with Michael addition reaction between hydrophobic thiol and hydrophilic tri-glycerol diacrylate. The solvent free reaction and purification by simply solvent extraction instead of any sophisticated chromatographic techniques provide an upper edge for their application in biomedical or other fields. These β-thiopropionate esters can potentially be used for the delivery and release of hydrophobic drugs at acidic sites particularly in cancer cells.
Justicia adhatoda L. is an Indian medicinal plant traditionally used to treat respiratory ailments in Ayurvedic and Unani medicines. It is widespread in the Indian subcontinent. The plant leaves are known to have broad range of pharmacological activities including analgesic, anti-inflammatory, antispasmodic and antibacterial properties. Some studies have highlighted the antimicrobial effects of its major bioactive components like vasicine and vasicinone However, not much work has been done to explore the enormous benefits that the bioactive components might hold. Hence, in the present study, we explored the plant for its potential as an effective anti- mycobacterial agent. We aim to investigate the antimycobacterial effect of J. adhatoda L. plant leaf extracts on Mycobacterium smegmatis and Mycobacterium bovis (BCG) and identify, and isolate th bioactive component(s) for the plant leaf extract. The isolated components were also analyzed further for their antimycobacterial activity in synergy with Isoniazid. The leaves of J. adhatoda L. were powdered and extracted with ethanol, water, ethyl acetate, and hexane and antimycobacterial activity was assessed by MABA. The ethanol extract showed >96% and 98% reduction in colony-forming units (CFU) at 100µg/ml on Mycobacterium smegmatis and Mycobacterium bovis (BCG) respectively. Active phytoconstituent from ethanol extract was isolated and further fractionated via Prep-TLC. They were bioassayed against M. smegmatis and M. bovis (BCG) to study cytotoxicity, synergy, and external damage on the bacteria. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) were carried out on treated bacilli to observe the external and internal cellular damage. The isolated fractions showed strong anti-mycobacterial activity, with low cytotoxicity and synergism when used with isoniazid. When subjected to electron microscopy, the fractions were found to adversely affect the cell wall and membrane of BCG, causing cytoplasmic leakage. Our study demonstrated that the active fractions isolated from J. adhatoda L. could be evaluated further for potentially effective anti-mycobacterial agents.
A special thematic issue meant to cover the various aspects of emerging infectious diseases, problems, and solutions to deal with possible infections of future.
Amidst the present pandemic, there has been a lot of talk about the role of immunity in handling the outbreak. A sudden surge of information on various aspects of immunity in infections has ignited curiosity and awareness among the common people about the role and scope of immunity.
The University of Delhi, Daulat Ram College ( https://dr.du.ac.in ) hosted a 3-day International Conference on “Infections and Immunity” on 8-10 Oct 2021 with aim towards a global collaboration between scientists, research scholars and students working on various aspects of immunology from different research organizations, medical institutions, NGOs, and reputed Universities, to share their ideas and discuss the solutions. The selected full length articles from speakers, participants and other scholars will be published in special thematic issue.
This special issue is meant to cover the various aspects of emerging infectious diseases, problems, and solutions to deal with possible infections of future. It will bring together the knowledge of the paradigms of infectious diseases and the recent researches related to this area including the role of both innate and acquired immunity. It also aims to explore the role of vaccine and the challenges in vaccine development against the infectious agents. The special issue will include articles on recent therapeutic and diagnostic tools in tackling infections, developments and challenges in vaccine and immunity with emphasis on most recent research findings.
Themes of special issue and associated Session of Conference are:
Infections: Bacterial, Viral and parasitic
Vaccine design and efficacy of immune system
Immune system and cancer
Genomic surveillance of infection agents
Role of Artificial intelligence in disease treatment
COVID-19 treatment and Management
Guest editors
Dr. Indrakant K. Singh, Associate Professor, Zoology Deshbandhu College, University of Delhi
Dr. Rajesh Pandey Associate Professor, (AcSIR) Principal Scientist, (CSIR-IGIB), Delhi
Coordinated by Dr. Jyoti Taneja Zoology Daulat Ram College, University of Delhi, Delhi.
Dr. Sonika Sharma Department of Zoology Daulat Ram College, University of Delhi, Delhi.
A long term Cell Culture and Insect Extracts T.N.Bankar1 and R.S.Pandit
Recommended for : JBTS / JIST
HIV infection and vaccine Dr. RAJNI ARORA SWAMI SHRADDHANAND COLLEGE, ALIPUR, (UNIVERSITY OF DELHI), DELHI-110036
Recommended for : JBTS / JIST
Prevention and management of the Severe Acute Respiratory Syndrome Coronavirus- 2 (SARS CoV-2) through endogenous Nitric Oxide production during Bhramari Pranayama- A review Chitra Chand,1 Dhananjoy Shaw,2* Vinod Kumar Katiyar3
The Lead Journal of Organic Chemistry, Heterocyclic Chemistry, Macrocyclic Chemistry, Synthetic Organic Chemistry, Catalysts and Catalysis, Polymer Chemistry, Materials Chemistry, Medicinal Chemistry, Environmental Chemistry and allied chemistry research advances.
The ChemCyclic Letters is rechristened ‘Advanced Organic Chemistry Letters’ (AOCL) international journal meant to provide a rapid forum for publication of quality original research from organic chemistry and interdisciplinary chemistry research. The ChemCyclic Letters covers the scientific ideas and approaches of synthetic organic chemistry, catalysis, new methodologies, natural product synthesis, new reaction pathways, peptide synthesis, small molecule synthesis, Chemistry research, chemical technology and other allied areas covering advances in chemistry.
The journal publishes research articles, review article, tutorial articles, expert opinions from all field of organic chemistry and allied chemistry research including Synthetic Organic Chemistry, Catalysis, Heterocyclic Chemistry, Macrocyclic chemistry, Polymer Chemistry, NanoChemistry, Chemical Engineering and all other research advances related to mew chemistry development. Researchers may please submit article on journal site
Author guidelines and article template for new chemistry letters journal ‘ChemCyclic Letters’ for Organic Chemistry, Heterocyclic, Macrocyclic, Synthesis, and all chemistry related research
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In a stride to provide the quality research contents for scientific fraternity as evident by our leading journals like Chemical Biology Letters and J Materials NanoScience, the ScienceIn is introducing a new journal ‘Molecular PhytoMedicine’ to serve the relevant community of researchers in the field of plant medicines, new chemical entities from plants for drug development, biochemistry of plant metabolites, and all related research fields.
The Journal
Molecular Phytomedicine is the lead peer reviewed international journal for integrated research coverage of therapeutics development from plants, natural products chemistry, medicinal plants, plant pharmaceuticals, herbal medicine, biochemisty of medicinal plant molecules and metabolites, biotechnology, chemistry of extracts and medicinal plants, ayurveda, medicines from algae, nanomedicine, plant pigments, and all related research meant for discovery of medicines from plants.
All articles will be peer-reviewed. Authors will retain the rights for published article (CC 4.0 BY license). There is NO open access fee for authors (all charges completely waived off).
Digital sensors for detecting toxic gas leaks N. Malathi , Arun A.D., S. Chithrakkumar, M. Sivaramakrishna, Arindam Das, G. Mangamma, Arun K Prasad, S. Dhara J. Mater. NanoScience, 2022, 9(2), 147-152 Link
Issue Details
This issue is focused on bringing together the research fraternity involved in chemi-resistive gas sensing in India. Gas sensing has widely evolved over the last two decades. It is imperative that as a nation, we address issues concerning the direction in which it is progressing in this country. Along with the plethora of research groups currently pursuing gas sensing research, recent trends and achievements in gas sensors at nanoscale has to be identified. This issue welcomes original research contributions in interdisciplinary areas such as synthesis, characterization, gas sensing, mechanism, modeling and applications.
Topics
Inorganic Nanomaterials (nanotubes, nanorods, nanowires, nanoparticles) for Gas Sensing
Organic materials for Gas Sensing (CNTs, Graphene, Polymers)
The standard processing policy of the journal will be applicable to the special issue. The articles will be evaluated via peer-review and guest editors will take decision based on reviewers feedback. Authors need to follow the guidelines provided on journal site.
The queries should be forwarded directly to topic editor or editorial office at pubs @ thesciencein (dot) org
One of the first-line therapy of diabetes mellitus is alpha-glucosidase inhibitors. Due to side effects caused by synthetic drugs and limited sources, various studies have been conducted on herbal plants and macroalgae consisting of bioactive compounds with alpha-glucosidase inhibitory activity. This study examines the alpha-glucosidase inhibitory activity and phytochemical compounds in ethyl acetate and ethanol extract of Bornetella oligospora, an abundant green alga in eastern Indonesia. The result showed that ethanol and ethyl acetate extract of Bornetella oligospora contained phytochemical components such as flavonoid, glycoside, triterpenoid, and steroid. The thin layer chromatography test showed ethanol extract have five spots with Rf 0.545, 0.527, 0.5, 0.473, and 0.154, while the ethyl acetate extract has two spots with Rf 0.58 and 0.64. The alpha-glucosidase inhibition assay showed IC50 values of the ethanol extract was 11.702 ug/mL and ethyl acetate extract was 95.384 ug/mL. In conclusion, Bornetella oligospora extract has the potential as an antidiabetic agent.
Siswanto, M. A., Paramita, R. I., Fadilah, F., & Poerwaningsih, E. H. (2021). Phytochemical and in vitro analysis of Bornetella oligospora extract as alpha-Glucosidase inhibitor. Chemical Biology Letters, 8(1), 40–44. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/120
Effect of astaxanthin from Haematococcus pluvialis on lipid peroxidation and oxidative stress induced by ambient air exposure was studied. Wistar albino rats were exposed to ambient air was administered with astaxanthin in doses varying between 0.5 to 2% of food intake. Various biological parameters like ALT, AST, ALP, malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase and glutathione reductase, were estimated biochemically and the expression of Nrf2 and glutathione peroxidase genes were estimated by reverse transcriptase PCR. Plasma ALT, AST, ALP, MDA and the activity of antioxidant enzymes; SOD, GRd, catalase were found increased significantly in ambient air exposed rats. Ambient air exposure decreased the levels of glutathione, non protein thiols and GPx expression whereas total thiols and expression of Nrf2 increased. However the concurrent administration of astaxanthin was found to reverse these changes in a dose dependent manner. The results of this study revealed the ability of astaxanthin to alleviate liver toxicity and oxidative stress induced by ambient air exposure and points to the possibility of developing astaxanthin as a dietary supplement that reduce the ill effect of toxic chemicals from ambient air.
Johnson, J. P., Renganthan, S., Menon, A., & Pillai, R. G. (2021). Beneficial impacts of Astaxanthin on Biomarkers of Antioxidant status and oxidative damage in Rats exposed to Ambient air. Chemical Biology Letters, 8(1), 1–9. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/158
Special issue on Biosensors: materials and methods
Lead 20 program
Any deviation or imbalance from homeostatic state of steady internal physical and chemical conditions in living systems, generally falls under category of disease. Chances of bringing them back to normalcy or closer to healthier state with therapeutic interventions are found to be more successful when they are applied at very early stage. Biosensing has emerged as a process to achieve early detection of deviations in such homeostatic states via evaluation of physiological, chemical, or biomolecular parameters in the subjects. The two main components on which efficiency of biosensors rely are materials used as platform technology and methods of detection used for the task. In this issue we will be assembling recent advancements in the field of Biosensors in terms of used materials and methods in achieving high sensitivity, specificity and predictability in form of original research.
Topic Editor
Santosh Misra, Ph.D. Dept of Biological Sciences & Bioengineering, Indian Institute of Technology, IIT Kanpur, U.P., IN
Schedule – The dates
Article Submission: January 31, 2022 (Processing – ‘as we go’ model) Issue completion: May 30, 2022
Field – Research area Biosensors NanoMedicine & Biomaterials NanoChemistry and Chemistry Materials NanoScience Nanotechnology Polymer and Functional Materials Materials Science
This special issue is under the Lead 20 program where leading scientists/academicians in the above field with well established lab, good publication record (an online link in form is required) and are under the age of 40 will be eligible to participate in this compilation. The editor will choose the best leading scholars from all the submitted entries (selection will be at abstract submission level as well as at full article level through peer review.
Authors / Abstracts
This is new recent Topic announced, the list of authors/abstracts will be updated here. This is an open invitations for interested researchers to submit the abstract for this topic. Submit the abstract with detail below:
The abstract details can also be forwarded directly to topic editor or editorial office at pubs @ thesciencein (dot) org
