Chemical Biology Letters http://pubs.thesciencein.org/journal/index.php/cbl <p>Chemical Biology Letters is an interdisciplinary international research journal for publication of research advances in Medicinal Chemistry, Biochemistry, Biotechnology, Chemical Biology, Drug Discovery, Drug Delivery, and related fields for understanding biological phenomenon at molecular level.</p> ScienceIn Publishing en-US Chemical Biology Letters 2347-9825 Mechanistic approach of anti-diabetic compounds identified from natural sources http://pubs.thesciencein.org/journal/index.php/cbl/article/view/59 <p>Type-2 diabetes mellitus (T2DM) is a global disease, which leads to various other life threatening diseases and affects the quality of life. Current therapies of T2DM have various side effects and ultimately lead to insulin resistance, along with financial burden. Therefore, comparative study of natural compounds along with their mechanisms has been discussed, which may lead toward better understanding of their efficacy and selection of future anti-diabetic drugs. Traditional medicine is promising to treat T2DM, where more than 200 plants and other species are shown to have anti-T2DM effects. Moreover, these natural products have different types of molecular mechanisms, i. e. β-cell regeneration, insulin mimicry, AMPK, Akt, PPARs, LXR activation and inhibition of α-glucosidase, TNF- α, sodium glucose co- tranporters and oxidative stress. At the same time, a number of compounds have been reported to have <em>in vivo</em> efficacy. As number of investigators have speculated the molecular mechanism of these natural opmpounds, this review is focused on the molecular mechanism of different types of natural anti-diabetic molecules and their classes along with their efficacy in animal models. This review will provide a broad idea about anti-diabetic compounds to scientific and common people and will help to choose the dietary components and traditional medicines effective in T2DM.</p> Rajesh Dabur Bhawana Sharma Ashwani Mittal ##submission.copyrightStatement## 2018-09-10 2018-09-10 5 2 63 99 Design, synthesis and Structure-Activity Relationship of novel Phenolic based Pyrimidine hybrids from Cashew Nut Shell Liquid (CNSL) components as potential antitumor agents http://pubs.thesciencein.org/journal/index.php/cbl/article/view/57 <p class="05Abstracttext">Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (<strong>15a-15t</strong>) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut shell liquid (CNSL). All the newly synthesized compounds were screened for their in vitro antitumor activity. Baylis-Hillman compounds <strong>5b </strong>and <strong>5h</strong> showed promising anticancer activity against MCF-7. Among pyrimidine derivatives, compounds <strong>15i</strong>, <strong>15j</strong> and <strong>15l</strong> showed promising activity against HEP-G2, whereas compounds <strong>15j</strong>, <strong>15k</strong>, <strong>15l</strong> and <strong>15m</strong> showed promising activity against MCF-7. In addition, compound <strong>15m</strong> showed significant activity against K562 when compared with the standard. The structure-activity relationship (SAR) analysis suggests that the length of the carbon chain of phenyl ring played an important role in the potency of activity.</p> Dênis Pires de Lima Thatikonda Narendar Reddy Adilson Beatriz Rosangela da Silva Lopes Maria Rita Marques Edson dos Anjos dos Santos Camila Izabela Nantes Maria de Fátima Cepa Matos Renata Trentin Perdomo Indiara Correia Pereira Simone Schneider Weber ##submission.copyrightStatement## 2018-01-31 2018-01-31 5 2 41 54 Antimycobacterial activity of Schiff’s Bases synthesized from substituted Benzaldehyde active against Mycobacterium http://pubs.thesciencein.org/journal/index.php/cbl/article/view/58 <p>In a preliminary screening we found that few substituted benzaldehyde have growth inhibitory effect against Mycobacterium. Study was planned to convert these substituted benzaldehyde to antimycobacterial Schiff’s bases. Schiff’s bases were synthesized by condensation of 2-Amino pyridine/ its derivative or Thiophene/ Furoic/ Nicotinic acid hydrazide with these substituted benzaldehydes. Compounds were purified and characterized by IR, <sup>1</sup>H and <sup>13</sup>C-NMR and were subjected to Antimycobacterial testing in two of the Mycobacterial strains; fast growing <em>Mycobacterium smegmatis</em> by disc diffusion method and further in to slow growing <em>Mycobacterium bovis</em> BCG strain using quantitative resazurin microplate assay. Schiff’s bases 3c, 3f and 8a have shown 60, 40 and 50 mm zone of inhibition in <em>M. smegmatis,</em> compared to control, Isoniazid showed 40 mm zone of inhibition. In <em>Mycobacterium bovis,</em> compounds 3c, 3f and 8a showed 53.69, 49.41, and 46.49 % of cell killing at 500 µM, the activity was concentration dependent and reduced viability of 29.73, 37.75 and 36.15% were reported at 125 µM. Isoniazid has shown 60% cell killing at 40 µg/ml. Schiff’s bases prepared from 4-hydroxy or 4-Nitro benzaldehyde with 2-amino pyridine (3c and 3f) and 2, 3 Dihydroxy benzaldehyde with nicotinic acid hydrazide (8a) have shown promising antimycobacterial potential.</p> Deeksha Sharma Niharika Sinha Anjana Sarkar Rajesh Kumar Gupta ##submission.copyrightStatement## 2018-08-25 2018-08-25 5 2 55 62