1,5-Benzothiazepine: Bioactivity and targets



  • Rajneesh Kaur Maharishi Markandeshwar University
  • Raman Singh Maharishi Markandeshwar University
  • Kuldeep Singh Maharishi Markandeshwar University


1,5-Benzothiazepine nucleus is present in a number of clinically used drugs such as diltiazem, clentiazem, thiazesim, quetiapine, and clothiapine. 1,5-Benzothiazepine can be easily introduced in the molecule having 2-aminothiophenol moiety. This article considers various targets for 1,5-benzothiazepine nucleus to establish structural activity relationship. It is an attempt to compile account of various structural modification in 1,5-benzothiazepine scaffold as reported for their versatile biological activities. This review would provide a platforms for selection of suitable moieties and development of specific chemical entities with desired features.

Author Biography

Rajneesh Kaur, Maharishi Markandeshwar University

Department of Chemistry



How to Cite

Kaur, R., Singh, R., & Singh, K. (2016). 1,5-Benzothiazepine: Bioactivity and targets. Chemical Biology Letters, 3(1), 18–31. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/96



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