1,5-Benzothiazepine: Bioactivity and targets

Authors

  • Rajneesh Kaur Maharishi Markandeshwar University
  • Raman Singh Maharishi Markandeshwar University
  • Kuldeep Singh Maharishi Markandeshwar University

Abstract

1,5-Benzothiazepine nucleus is present in a number of clinically used drugs such as diltiazem, clentiazem, thiazesim, quetiapine, and clothiapine. 1,5-Benzothiazepine can be easily introduced in the molecule having 2-aminothiophenol moiety. This article considers various targets for 1,5-benzothiazepine nucleus to establish structural activity relationship. It is an attempt to compile account of various structural modification in 1,5-benzothiazepine scaffold as reported for their versatile biological activities. This review would provide a platforms for selection of suitable moieties and development of specific chemical entities with desired features.

Author Biography

Rajneesh Kaur, Maharishi Markandeshwar University

Department of Chemistry

Benzothiazepine

Published

2016-04-22

How to Cite

Kaur, R., Singh, R., & Singh, K. (2016). 1,5-Benzothiazepine: Bioactivity and targets. Chemical Biology Letters, 3(1), 18–31. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/96

Issue

Section

Review Articles