Synthesis of novel Imidazo [1,2-b] pyridazine derivatives and study of their biomedicinal efficacy

  • Ashish Bhatt Mewar University
  • Rajesh Kumar Singh Mewar University
  • Ravi Kant Mewar University
Keywords: Antimicrobial, Antimalarial, pyridazine

Abstract

Novel 2-Substituted aryl (or alkyl)-6-(substituted aryl) imidazo[1,2-b]pyridazine derivatives have been synthesized by the suzuki reaction of 6-chloro-2-substituted aryl(or alkyl) imidazo[1,2-b]pyridazine  [obtained by the reaction of 3-amino-6-chloro pyridazine with 2-bromo-1-substituted aryl (or alkyl) ethanone] with substituted aryl boronic acid in presence of  bis(triphenylphosphine)palladium(ii) chloride and potassium carbonate in dimethyl formamide. These were screened for in-vitro antimicrobial activity against two gram positive (Streptococcus pyogenes and Staphylococcus aureus ) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli) as well as for antifungal and antimalarial activity against Plasmodium falciparum strain. Compound 2f and 2g exhibited good antimicrobial and antimalarial activity.

antibacterial activity of imidazo[1,2-b]pyridazine
Published
2016-09-01
How to Cite
Bhatt, A., Singh, R., & Kant, R. (2016). Synthesis of novel Imidazo [1,2-b] pyridazine derivatives and study of their biomedicinal efficacy. Chemical Biology Letters, 3(2), 38-43. Retrieved from http://pubs.thesciencein.org/journal/index.php/cbl/article/view/38
Section
Research Articles