Tetrahedral Hydroxyethylamine: A Privileged Scaffold in Development of Antimalarial Agents

  • Brijesh Rathi University of Delhi
  • Prem Prakash Sharma University of Delhi
  • R.P. Singh University of Delhi
Keywords: Hydroxyethylamine, Malaria, Plasmepsin

Abstract

Hydroxyethylamine (HEA) based small molecules have extensively been evaluated for their antimalarial properties. HEA scaffold enabled generation of numerous chemical libraries with significant antimalarial activity. Besides, the tetrahedral HEA scaffold has been explored for the construction of inhibitors of malarial aspartic proteases, plasmepsin 1 and 2. This review deals with chemistry and evaluation of HEA based small molecules as antimalarial agents.

Published
2014-02-02
How to Cite
Rathi, B., Sharma, P., & Singh, R. (2014). Tetrahedral Hydroxyethylamine: A Privileged Scaffold in Development of Antimalarial Agents. Chemical Biology Letters, 1(1), 11-13. Retrieved from http://pubs.thesciencein.org/journal/index.php/cbl/article/view/20
Section
Research Articles