Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?

Authors

  • Smriti Sharma University of Delhi
  • Vinayak Bhatia ICARE Eye Hospital and Postgraduate Institute

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome, which occurs due to increased glucose levels in the human body. There has been lot of work in developing novel approaches to tackle this disease. GLP-1 receptor (GLP-1R), one of the class-B G-protein-coupled receptors (GPCR), is a budding molecular target to design drugs for treating type 2 diabetes. In this review, authors have summarized the physiological actions of Glucagon-like peptide-1 receptor (GLP-1R) and current available drugs based on GLP-1 RAs. Some of the exemplary studies in this area have been examined in detail. Authors conclude that development of degradation-resistant, long-acting GLP-1 receptor agonists is a promising area of research and lot of work needs to be done to understand its mechanism of action.

Author Biography

  • Smriti Sharma, University of Delhi

    Department of Chemistry, Miranda House, University of Delhi, India

GLP agonist diabetes

Published

2020-08-14

Issue

Section

Review Articles

How to Cite

Treatment of Type 2 diabetes mellitus (T2DM): Can GLP-1 Receptor Agonists fill in the gaps?. (2020). Chemical Biology Letters, 7(4), 215-224. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/132