by Prof. Anant Hardas
Published in Journal of Biomedical and Therapeutic Sciences BiomedFrontiers section (Print)
The first issue of Pharmacy Journal in India – The Indian Journal of Pharmacy was published in Dec 1894, however it was defunct after 3 years. The Modern Pharmaceutical Journalism in India was Pioneered by Mr. Premnath Bazaz, who started the Eastern Pharmacist in 1958 and equal contribution was by Dr. A.K. Patni, who edited Indian Drug since its inception published by IDMA. Today there are nearly 175 Pharmacy Journal published in mostly English (and also in Marathi, Hindi & Bengali) by 5 different categories of publishers in India. The PCI has set out official Journals – seven – for D. Pharm Course and 20 for B. Pharm Degree Course, and minimum 2 international Journals for each discipline of specialization at M. Pharm, Ph.D and Pharm. D Courses structure in India. This article brings out short History and progress of Indian Pharmacy Periodical as on today.
Improved electrochemical performance of free standing electrospun graphene incorporated carbon nanofibers for supercapacitor
Published in Journal of Materials NanoScience
Dipti V Jamkar
Rashtrasant Tukadoji Maharaj Nagpur University
Balkrishna J. Lokhande
Subhash B. Kondawar
Rashtrasant Tukadoji Maharaj Nagpur University
Carbon nanofibers, graphene,
electrospinning, electrochemical performance,
In this paper, we report the fabrication of carbon nanofibers (CNFs) by electrospinning of polyacrylonitrile (PAN) solution in N,N-dimethylformamide (DMF)with different concentrations followed by stabilization and carbonization in a tubular quartz furnace. To improve the electrochemical performance, graphene nanosheets have been used to prepare porous graphene/carbon nanofibers (G-CNFs). The morphology of the porous G-CNFs were characterized by means of scanning electron microscopy (SEM). Diameter of CNFs and G-CNFs were found to be in the range of 400 – 500 nm reveals the fibers in nanoscale with high porosity. The electrochemical performance of as-synthesized CNFs and G-CNFs was studied by cyclic voltammetry (CV), galvanostatic charge discharge (GCD) and electrochemical impedance spectroscopy. The CV curve of the pure CNFs show distorted rectangular shape whereas CV curve of G-CNFs exhibit a nearly rectangle-shaped profile which is the characteristic of an ideal electric double-layer capacitor. The improved electrochemical performance of G-CNFs is due to the improved internal electrical conductivity of G-CNFs via graphene nanosheets interlaying.
Jamkar, D., Lokhande, B., & Kondawar, S. (2019). Improved electrochemical performance of free standing electrospun graphene incorporated carbon nanofibers for supercapacitor. Journal of Materials NanoScience, 6(1), 32-37.
Retrieved full text from http://pubs.thesciencein.org/journal/index.php/jmns/article/view/94
Recent advances in metal nanoparticles supported on Montmorillonite as catalysts for organic synthesis
Published in Journal of Materials NanoScience
- Dipak Kumar Dutta
CSIR-North East Institute of Science and Technology, Materials Sciences and Technology Division, Jorhat 785006, Assam
Metal-Nanoparticles, Supported Catalysts,
Heterogeneous Catalysts, Organic Synthesis
Nanostructured materials has appealed considerable attention due to their characteristic properties and applications in different fields. Metal nanoparticles supported on modified montmorillonite composites have led to the generation of new and novel heterogeneous ‘Nanocatalysts’, which are much more efficient than other catalysts and thus pave the way for developing sustainable environmentally benign catalysis and chemical procedures. Such nanocatalysts are progressing towards their use in chemical industries. This review presents the recent trend of advances in the synthesis and catalytic reactions of supported metal nanoparticles on acid activated montmorillonite. Metals nanoparticles-montmorillonite composites show efficient catalytic activities with high conversions and selectivity for hydrogenation, transfer hydrogenation, oxidations and coupling reactions. Raw montmorillonite possess no catalytic activity, however acid activated montmorillonite exhibits excellent acid catalytic activities.
Dutta, D. (2019). Recent advances in metal nanoparticles supported on Montmorillonite as catalysts for organic synthesis. Journal of Materials NanoScience, 6(1), 19-31.
Retrieve full text from http://pubs.thesciencein.org/journal/index.php/jmns/article/view/87
Formulation optimization of multicomponent aqueous coground mixtures of Meloxicam for dissolution enhancement
Multicomponent coground mixtures of meloxicam
Published in Chemical Biology Letters
University of Puerto Rico
factorial design, solubility,
drug delivery, hyrophilicity, PEG
In present work, the role of various formulation excipients for
dissolution enhancement of a BCS Class II drug, meloxicam was studied by
formulating multicomponent aqueous coground mixtures using lactose,
microcrystalline cellulose and three solubilizers; polyethylene glycol
400, propylene glycol and polyvinyl pyrrolidone. A 33 full factorial design was employed using solubilizers’ concentrations as independent variables whereas angle of repose and in vitro
drug dissolution as dependent variables in order to optimize the
amounts of solubilizers. The results revealed more than fivefold
increase in drug dissolution in some experimental batches compared to
that of pure drug powder. Full and reduced models were evolved for the
dependent variables and the reduced models were further validated using
extra design check points. The studies suggested that the incorporation
of optimized amounts of solubilizers could be successfully employed for
achieving desired flow properties and enhanced drug dissolution of
poorly water soluble meloxicam. The method emerged as a simple,
cost-effective, and organic solvent-free green approach toward
formulation development of meloxicam and may also be applied to other
limited water-soluble drugs.
Dahiya, S., Kaushik, A., & Pathak, K. (2019). Formulation optimization of multicomponent aqueous coground mixtures of Meloxicam for dissolution enhancement. Chemical Biology Letters, 6(1), 1-7.
Full text link http://pubs.thesciencein.org/journal/index.php/cbl/article/view/93
Antidiabetic effect of Carissa carandas in rats and the possible mechanism of its insulin secretagogues activity in isolated pancreatic islets
Indira Gandhi National Tribal University
Antidiabetic, Solvent Extract,
Insulin, Plant fruits, phytochemicals,
Carissa carandas (CC) has been used in folklore medicine for treatment of diabetes. In the present study, hexane, chloroform, ethyl acetate, methanol and aqueous extracts of CC fruit were examined for hypoglycemic activity in healthy Wistar rats. Aqueous Extract of CC (AECC) was most active and showed fall of 67.08% in fasting blood glucose from 0 to 1h in glucose tolerance test (GTT). The ED50 of AECC was 300mg/kgbw in streptozotocin induced diabetic rats. Treatment of diabetic rats with ED50 of AECC for 28 days significantly reduced post prandial glucose (PPG) by 33.65% (p<0.01), glycosylated hemoglobin (HbA1c) by 45.79% (p<0.01) and increased insulin level by 69.7% (p<0.05). The results indicated that increase in insulin secretion may be partly responsible for antidiabetic effect of AECC. To assess the mechanism of secretagogues activity, AECC was incubated with isolated pancreatic islets of healthy Wistar rats at basal (3.3mM) and high (16.7mM) level of glucose in presence or absence of Diazoxide (K-ATP channel opener), Nimodipine (Ca2+ Channel blocker) and Calphostin-C (PKC inhibitor). AECC induced insulin secretion at 16.7mM of glucose was significantly (p<0.01) reduced by Diazoxide and Nimodipine but non significantly (p>0.05) by Calphostin-C. The study indicated that the phytochemicals present in AECC may be inducing insulin secretion by closing K-ATP channels in β-cells of pancreatic islets.
Full text link: http://pubs.thesciencein.org/journal/index.php/jbts/article/view/90
Nanochemistry and Nanocatalysis Science: Research advances and
Bhupender S. Chhikara, Rajender S. Varma
The development of nanomaterials has made its mark in nanocatalytic applications and ensuing plethora of nanotechnological advances. The size-dependent chemistry of nanomaterials and consequent controlled and designed synthesis of smart materials with desired end application has provided us a number of new products recently which are already making impact on quality of human life. The fundamental nano paradigm shift would influence future research advances in field of nanoscience chemistry, ranging from drug delivery to exquisite designs of novel catalysts that drive innovations in chemical synthesis and transformations. The nanoscience is an interdisciplinary field that will see increased role in the diverse and emerging newer areas like artificial intelligence; nanochemistry would help speed up the development of applications in the real world with artificial intelligence.
Full text link: http://pubs.thesciencein.org/journal/index.php/jmns/article/view/88
Synthesis and Biodegradation Study of Starch/PVA/Nanoclay Blend
Geeta Saini University of Delhi
Himani Chauhan University of Delhi
Aeshna Gupta University of Delhi
Disha Gangotia University of Delhi
Keywords: Food packaging, Nanoclay, Biodegradable, PVA, Starch
In this research work, we have synthesized blend of starch/PVA/nanoclay via solution cast method. The composition of blend was starch and PVA in 1:1 ratio by weight with citric acid as plasticizer. The amount of nanoclay was varied between 0.5 to 2 wt%. The structure elucidation of the film by Scanning electron microscopy reveals homogeneous dispersion of nanoclay into polymer matrix. The biodegradation of the films were studied by soil burial method and enzymatic hydrolysis and it was found that completely biodegradable films were produced which could serve as potential candidate for food packaging.
Herbal nanomedicine interactions to enhance pharmacokinetics, pharmaco-dynamics, and therapeutic index for better bioavailability and biocompatibility of herbal formulations
Rajiv Kumar University of Delhi
Munesh Sharma Arogya Nidhi Ayurveda Clinic
Keywords: Phyto-medicine, Hydrophilicity, Nanocarriers, Drug Delivery
The recent technological advancement in nanotechnology has opened new avenues for research and development in the field of phyto-medicine. Development of reliable and eco-friendly synthesis of nanoparticles is a significant advancement for introduction nanotechnology to develop noble nanomedical delivery system of herbs (HNMDS), and have to overcome the downsides of old-style herbs-medicines delivery through analyzing the interactions between nanocarriers and herbs or phyto-medicine. The application of nanotechnological methods for bioavailability and biocompatibility enhancement of phyto-medicine must be reviewed and need urgent prompt efforts to develop new formulations. Nanotechnology enables the combination of hitherto separate approaches to health care by permitting the realization of so-called ’theranostic’ applications, as well as targeted combination products. Formulation must also release active ingredient from phyto-formulation as developing nano dosage forms has number of benefits for phyto-medicine. This review discusses nano sized herbs-nanomedicines delivery carries and potential current and futuristic advances for enhancing the activity and overcoming problems associated with herbal medicines for novel HNMDS.