Antidiabetic effect of Carissa carandas in rats and the possible mechanism of its insulin secretagogues activity in isolated pancreatic islets
Indira Gandhi National Tribal University
Antidiabetic, Solvent Extract,
Insulin, Plant fruits, phytochemicals,
Carissa carandas (CC) has been used in folklore medicine for treatment of diabetes. In the present study, hexane, chloroform, ethyl acetate, methanol and aqueous extracts of CC fruit were examined for hypoglycemic activity in healthy Wistar rats. Aqueous Extract of CC (AECC) was most active and showed fall of 67.08% in fasting blood glucose from 0 to 1h in glucose tolerance test (GTT). The ED50 of AECC was 300mg/kgbw in streptozotocin induced diabetic rats. Treatment of diabetic rats with ED50 of AECC for 28 days significantly reduced post prandial glucose (PPG) by 33.65% (p<0.01), glycosylated hemoglobin (HbA1c) by 45.79% (p<0.01) and increased insulin level by 69.7% (p<0.05). The results indicated that increase in insulin secretion may be partly responsible for antidiabetic effect of AECC. To assess the mechanism of secretagogues activity, AECC was incubated with isolated pancreatic islets of healthy Wistar rats at basal (3.3mM) and high (16.7mM) level of glucose in presence or absence of Diazoxide (K-ATP channel opener), Nimodipine (Ca2+ Channel blocker) and Calphostin-C (PKC inhibitor). AECC induced insulin secretion at 16.7mM of glucose was significantly (p<0.01) reduced by Diazoxide and Nimodipine but non significantly (p>0.05) by Calphostin-C. The study indicated that the phytochemicals present in AECC may be inducing insulin secretion by closing K-ATP channels in β-cells of pancreatic islets.
Full text link: http://pubs.thesciencein.org/journal/index.php/jbts/article/view/90
Nanochemistry and Nanocatalysis Science: Research advances and
Bhupender S. Chhikara, Rajender S. Varma
The development of nanomaterials has made its mark in nanocatalytic applications and ensuing plethora of nanotechnological advances. The size-dependent chemistry of nanomaterials and consequent controlled and designed synthesis of smart materials with desired end application has provided us a number of new products recently which are already making impact on quality of human life. The fundamental nano paradigm shift would influence future research advances in field of nanoscience chemistry, ranging from drug delivery to exquisite designs of novel catalysts that drive innovations in chemical synthesis and transformations. The nanoscience is an interdisciplinary field that will see increased role in the diverse and emerging newer areas like artificial intelligence; nanochemistry would help speed up the development of applications in the real world with artificial intelligence.
Full text link: http://pubs.thesciencein.org/journal/index.php/jmns/article/view/88
Synthesis and Biodegradation Study of Starch/PVA/Nanoclay Blend
Geeta Saini University of Delhi
Himani Chauhan University of Delhi
Aeshna Gupta University of Delhi
Disha Gangotia University of Delhi
Keywords: Food packaging, Nanoclay, Biodegradable, PVA, Starch
In this research work, we have synthesized blend of starch/PVA/nanoclay via solution cast method. The composition of blend was starch and PVA in 1:1 ratio by weight with citric acid as plasticizer. The amount of nanoclay was varied between 0.5 to 2 wt%. The structure elucidation of the film by Scanning electron microscopy reveals homogeneous dispersion of nanoclay into polymer matrix. The biodegradation of the films were studied by soil burial method and enzymatic hydrolysis and it was found that completely biodegradable films were produced which could serve as potential candidate for food packaging.
Herbal nanomedicine interactions to enhance pharmacokinetics, pharmaco-dynamics, and therapeutic index for better bioavailability and biocompatibility of herbal formulations
Rajiv Kumar University of Delhi
Munesh Sharma Arogya Nidhi Ayurveda Clinic
Keywords: Phyto-medicine, Hydrophilicity, Nanocarriers, Drug Delivery
The recent technological advancement in nanotechnology has opened new avenues for research and development in the field of phyto-medicine. Development of reliable and eco-friendly synthesis of nanoparticles is a significant advancement for introduction nanotechnology to develop noble nanomedical delivery system of herbs (HNMDS), and have to overcome the downsides of old-style herbs-medicines delivery through analyzing the interactions between nanocarriers and herbs or phyto-medicine. The application of nanotechnological methods for bioavailability and biocompatibility enhancement of phyto-medicine must be reviewed and need urgent prompt efforts to develop new formulations. Nanotechnology enables the combination of hitherto separate approaches to health care by permitting the realization of so-called ’theranostic’ applications, as well as targeted combination products. Formulation must also release active ingredient from phyto-formulation as developing nano dosage forms has number of benefits for phyto-medicine. This review discusses nano sized herbs-nanomedicines delivery carries and potential current and futuristic advances for enhancing the activity and overcoming problems associated with herbal medicines for novel HNMDS.